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Publico-10940b.pdf: 1216468 bytes, checksum: bd1ea49c2bfdfa8789e58924c9513820 (MD5) / Nesta dissertação, são descritos os estudos visando a síntese total da isodolastatina H, um éster peptídico natural da família das dolastatinas com grande atividade citotóxica. O diferencial nesta sintese sobre as outras, foi a construcao das unidades gama-aminoacidos Dil e Dap, que foram obtidas via reacao de adicao de sais de crotil e aliltrifluoroboratos a L -prolinal e L -valinal, respectivamente. Os fragmentos foram posteriormente unidos por reacoes de esterificacao e amidacao. / This dissertation, are described the study towards to total synthesis of isodolastatin H, a natural peptide ester of dolastatin family with great citotoxicity activity. The main focus in this synthesis, is the construction of gama-aminoacid units Dil and Dap, obtained via addition reaction of crotyl and allyltrifluoroborate salts with L -prolinal and L-valinal, respectively. The junction of fragments was subsequently made from esterification and amidation reaction. / TEDE / BV UNIFESP: Teses e dissertações
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/9606 |
| Date | 27 February 2008 |
| Creators | Guarezemini, Alexandre Sardelli [UNIFESP] |
| Contributors | Universidade Federal de São Paulo (UNIFESP), Stefani, Helio Alexandre [UNIFESP] |
| Publisher | Universidade Federal de São Paulo (UNIFESP) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | 108 p. |
| Source | reponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP |
| Rights | info:eu-repo/semantics/openAccess |
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