Previous findings have indicated that oxidative stress plays a role in the development of osteoporosis and that individual polyphenols, by virtue of their antioxidant properties, may mitigate these damaging effects. Nutritional supplements, greens+ bone builderTM, containing polyphenols and other micronutrients beneficial for bone health are of recent interest as complementary strategies in the management of osteoporosis. A randomized controlled study was conducted to explore the combined effects of the nutrients found within the supplement on bone health for 8 weeks. Total polyphenol content and antioxidant capacity increased whereas oxidative stress parameters and the bone resorption marker, crosslinked C-telopeptide of type I collagen decreased after supplementation. There was no significant change in the bone formation marker, procollagen type I N-terminal propeptide. This thesis shows an association of polyphenols with other micronutrients acts through their antioxidant capacity to decrease oxidative stress parameters and bone resorption, thus potentially reducing the risk for osteoporosis.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33261 |
| Date | 20 November 2012 |
| Creators | Kang, Nancy |
| Contributors | Rao, A. Venketeshwer |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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