The literature contains indications that adrenaline antagonists inhibit muscarinic actions of acetylcholine, however, this is generally regarded as a weak and unspecific affect, and a quantitative evaluation has rarely been carried out. Employing the isolated guinea pig atrium and ileum, this study shows that phenoxybenzamine is a patent and specific atropine-like agent. Chlorpromazine is less patent than phenoxybenzamine, and other adrenaline antagonists - phentolamine, prosympal, and yohimbine – are even less patent than chlorpromazine. The work originated from observations that phenoxybenzamine reverses the effect of vagal stimulation on the isolated guinea pig atrium so that stimulation instead of inhibition occurs (Benfey and Greeff, 1961).
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115107 |
| Date | January 1963 |
| Creators | Grillo, Samuel. A. |
| Contributors | Benfey, B. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Health Sciences.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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