In earlier reported studies from this laboratory (Share and Melville, 1961; Varma et al, 1962; and Melville and Share, 1963) it was shown that injection of the convulsant drug, picrotoxin, into the lateral cerebral ventricles of cats and rabbits can lead to a rise in arterial blood pressure associated with various types of electrocardiographic ST-T alterations and cardiac arrhythmias (bradycardia, tachycardia, extrasystoles and even ventricular fibrillation in rabbits). It was suggested that these cardiovascular effects of picrotoxin were mediated through central excitation of adrenergic mechanisms, probably involving "release" of catecholamines (noradrenaline mainly) from the hypothalamus and midbrain.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115537 |
| Date | January 1964 |
| Creators | Huq, Shariful. |
| Contributors | Melville, K. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Health Sciences.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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