The primary object of this investigation was to study further the movement of labelled noradrenaline in the isolated perfused rabbit heart, with special reference to its significance in cardiac drug action. Since the movment (uptake and outflow) of noradrenaline might be influenced by changes in heart functions, e.g. coronary flow, heart rate and cardiac contractility, attempts were made to cerrelate movement of noradrenaline with changes in these functions. It is now clearly established that the heart can take up exogenous noradrenaline and that the absorbed noradrenaline appears to be localised at similar sites to those of the physiologically occurring amine. It has also been reported that radioactive labelled noradrenaline is retained by the heart for a long time in some type of inactive bound form [...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.116749 |
| Date | January 1965 |
| Creators | Agrawal, Krishan K. |
| Contributors | Melville, K. I. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Pharmacology. ) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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