The search for drugs to relieve angina pectoris has been primarily a search for agents which enhance coronary flow without significantly increasing cardiac oxygen demand. Glyceryltrinitrate (nitroglycerin) has long been used clinically in angina pectoris and remains the standard by which the potency of other agents may be classified. The exact cause of the benefit derived from nitroglycerin in cardiac ischemic disease is far from clear. Usually it is attributed to improved myocardial oxygenation resulting from coronary dilatation and/or reduced peripheral resistance with a reduction in myocardial oxygen requirement. [...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.117792 |
| Date | January 1965 |
| Creators | Gillis, Richard A. |
| Contributors | Melville, K. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Pharmacology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
Page generated in 0.0022 seconds