In 1856, Vulpian described the formation of a green colour when the adrenal medulla was moistened with ferric chloride; iodine produced a red coloration. The medulla was shown to develop a blue colour with ferric sulphate (Colin, 1856), while the formation of a brown colour on adding dichromate to adrenal extracts was described by Menle in 1865. These observations laid the foundation for subsequent attempts to estimate adrenaline by chemical means. Following the isolation of the physiologically active principle of the adrenal medulla, by Takamine and by Aldrich (1901), attempts were made to utilise various colour reactions for the estimation of adrenaline in medullary extracts.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.112025 |
| Date | January 1959 |
| Creators | Millar, Ronald. A. |
| Contributors | Benfey, B. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Health Sciences.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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