The importance of taxol as an anticancer drug lies not only in its activity in antitumor assays but also in its unique mechanism of action. Unfortunately, taxol is not water-soluble and therefore must be given in conjunction with emulsifying agents. Modifications of taxol were carried out in order to prepare water-soluble taxol derivatives. The C-2’ hydroxyl group of taxol was substituted with various groups to increase water solubility. The synthesized taxol derivatives, 2’-((3-sulfo-1-oxopropyl)oxy)taxol sodium salt, 2’-((4-((2-sulfoethyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt, and 2’-((4-((3-sulfopropyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt were more water-soluble than taxol. The synthetic pathways to these compounds are compared and discussed. / Master of Science
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/46002 |
| Date | 24 November 2009 |
| Creators | Zhao, Zhiyang |
| Contributors | Chemistry |
| Publisher | Virginia Tech |
| Source Sets | Virginia Tech Theses and Dissertation |
| Language | English |
| Detected Language | English |
| Type | Thesis, Text |
| Format | viii, 67 leaves, BTD, application/pdf, application/pdf |
| Rights | In Copyright, http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | OCLC# 24346600, LD5655.V855_1991.Z436.pdf |
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