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Modeling the Impact and Intervention of a Sexually Transmitted Disease: Human Papilloma Virus

Many human papilloma virus (HPV) types are sexually transmitted and HPV DNA types 16, 18, 31, and 45 account for more than 75% if all cervical dysplasia. Candidate vaccines are successfully completing US Federal Drug Agency (FDA) phase III testing and several drug companies are in licensing arbitration. Once this vaccine become available it is unlikely that 100% vaccination coverage will be probable; hence, the need for vaccination strategies that will have the greatest reduction on the endemic prevalence of HPV. This thesis introduces two discrete-time models for evaluating the effect of demographic-biased vaccination strategies: one model incorporates temporal demographics (i.e., age) in population compartments; the other non-temporal demographics (i.e., race, ethnicity). Also presented is an intuitive Web-based interface that was developed to allow the user to evaluate the effects on prevalence of a demographic-biased intervention by tailoring the model parameters to specific demographics and geographical region.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc5289
Date05 1900
CreatorsCorley, Courtney D.
ContributorsMikler, Armin R., Mihalcea, Rada, 1974-, Oppong, Joseph R., Cook, Diane, Singh, Karan
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
FormatText
RightsPublic, Copyright, Corley, Courtney D., Copyright is held by the author, unless otherwise noted. All rights reserved.

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