Stimulus-driven changes in the gain of sensory neurons are well-documented, but relatively little is known about whether analogous gain-control can also be effected in a top-down manner. A recent psychophysical study demonstrated that sensitivity to luminance contrast can be modulated by a priori knowledge (de la Rosa et al., in press). In the present study, event-related potentials were used to resolve the stages of information processing that facilitate such knowledge-driven adjustments. Groupwise independent component analysis identified two robust spatiotemporal patterns of endogenous brain activity that captured experimental effects. The first pattern was associated with obligatory processing of contextual information, while the second pattern
was associated with selective initiation of contrast gain adjustment. These data suggest
that knowledge-driven contrast gain control is mediated by multiple independent electrogenic sources.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/17439 |
| Date | 14 July 2009 |
| Creators | Misic, Bratislav |
| Contributors | McIntosh, Anthony Randal |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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