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Anatomic Patterns of Relapse and Progression Following Treatment with 131I-MIBG in Metastatic Neuroblastoma

A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. / Purpose and Background: Neuroblastomais the most common pediatric extracranialsolid tumor
•50% of patients present with metastatic disease typically involving bone and bone marrow
•Despite intensive multimodality therapy, 40% of patients with high-risk neuroblastomawill experience relapse
•131I-MIBG is an active salvage agent for relapsed and refractory MIBG-avid disease
•It is unknown whether disease progression following 131I-MIBG treatment occurs in previously involved vs. new sites of disease
•A better understanding of this pattern may inform the use of consolidative focal therapies following 131I-MIBG administration

Identiferoai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/627159
Date30 March 2018
CreatorsFishel Ben-Kenan, Rotem
ContributorsThe University of Arizona College of Medicine - Phoenix, Polishchuk, Alexei MD, PhD
PublisherThe University of Arizona.
Source SetsUniversity of Arizona
Languageen_US
Detected LanguageEnglish
TypeThesis
RightsCopyright © is held by the author. Digital access to this material is made possible by the College of Medicine - Phoenix, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.

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