by Wong Yick Fu. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1990. / Bibliography: leaves 201-224. / Acknowledgments --- p.V / Summary --- p.vi / Publications --- p.ix / Statement of Originality --- p.X / List of Abbreviations --- p.xi / Chapter Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Preamble --- p.2 / Chapter 1.2 --- History of Trichosanthin --- p.6 / Chapter 1.3 --- Preparation of Trichosanthin --- p.8 / Chapter 1.4 --- Chemistry of Trichosanthin --- p.10 / Chapter 1.4.1 --- Primary structure --- p.10 / Chapter 1.4.2 --- Three dimensional structure --- p.12 / Chapter 1.5 --- Pharmacology of Trichosanthin --- p.14 / Chapter 1.5.1 --- Pharmacologic action --- p.14 / Chapter 1.5.2 --- Pharmacokinetics --- p.18 / Chapter 1.5.3 --- Toxicity --- p.21 / Chapter 1.6 --- Clinical Use of Trichosanthin --- p.24 / Chapter 1.6.1 --- Clinical application --- p.24 / Chapter 1.6.2 --- Mechanism of action --- p.29 / Chapter 1.6.3 --- Adverse reactions --- p.31 / Chapter 1.6.4 --- Contraindications --- p.33 / Chapter 1.7 --- Objectives of Project and Organization of Thesis --- p.35 / Chapter Chapter 2 --- Anti-tumour Activity of Trichosanthin In Vitro and In Vivo --- p.37 / Chapter 2.1 --- Cytotoxic Effects of Trichosanthin on Cultured Tumour Cells --- p.38 / Chapter 2.1.1 --- Introduction --- p.38 / Chapter 2.1.2 --- Materials and methods --- p.40 / Chapter 2.1.3 --- Results --- p.49 / Chapter 2.1.4 --- Discussion --- p.59 / Chapter 2.2 --- Effects of Trichosanthin on Co-cultured Cell Lines In Vitro --- p.64 / Chapter 2.2.1 --- Introduction --- p.64 / Chapter 2.2.2 --- Materials and methods --- p.65 / Chapter 2.2.3 --- Results --- p.66 / Chapter 2.2.4 --- Discussion --- p.77 / Chapter 2.3 --- Combination Effects of Trichosanthin with Adriamycin and Cisplatin on Cultured Tumour Cells --- p.80 / Chapter 2.3.1 --- Introduction --- p.80 / Chapter 2.3.2 --- Materials and methods --- p.81 / Chapter 2.3.3 --- Results --- p.84 / Chapter 2.3.4 --- Discussion --- p.93 / Chapter 2.4 --- Effects of Trichosanthin on Choriocarcinoma Cells In Vivo --- p.96 / Chapter 2.4.1 --- Introduction --- p.96 / Chapter 2.4.2 --- Materials and methods --- p.97 / Chapter 2.4.3 --- Results --- p.101 / Chapter 2.4.4 --- Discussion --- p.107 / Chapter 2.5 --- Effects of Trichosanthin Protein and Polysaccharide on Choriocarcinoma Cells In Vitro --- p.110 / Chapter 2.5.1 --- Introduction --- p.110 / Chapter 2.5.2 --- Materials and methods --- p.112 / Chapter 2.5.3 --- Results --- p.114 / Chapter 2.5.4 --- Discussion --- p.117 / Chapter Chapter 3 --- Mechanism of Action of Trichosanthin on Tumour Cells --- p.119 / Chapter 3.1 --- Morphological Study of Effects of Trichosanthin on Cultured Choriocarcinoma Cells --- p.120 / Chapter 3.1.1 --- Introduction --- p.120 / Chapter 3.1.2 --- Materials and methods --- p.121 / Chapter 3.1.3 --- Results --- p.124 / Chapter 3.1.4 --- Discussion --- p.133 / Chapter 3.2 --- Binding of Radiolabelled Trichosanthin with Tumour Cells In Vitro --- p.137 / Chapter 3.2.1 --- Introduction --- p.137 / Chapter 3.2.2 --- Materials and methods --- p.138 / Chapter 3.2.3 --- Results --- p.146 / Chapter 3.2.4 --- Discussion --- p.154 / Chapter 3.3 --- Effects of Trichosanthin on Macromolecule Synthesis of Choriocarcinoma Cells In vitro --- p.159 / Chapter 3.3.1 --- Introduction --- p.159 / Chapter 3.3.2 --- Materials and methods --- p.160 / Chapter 3.3.3 --- Results --- p.163 / Chapter 3.3.4 --- Discussion --- p.167 / Chapter Chapter 4 --- General Discussion --- p.169 / Chapter 4.1 --- Anti-tumour Activity of Trichosanthin --- p.170 / Chapter 4.2 --- Mechanism of Action of Trichosanthin --- p.180 / Chapter 4.3 --- Prospects of Research on Trichosanthin --- p.195 / References --- p.201 / Appendix 1 --- p.225 / Appendix 2 --- p.242
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_318657 |
| Date | January 1990 |
| Contributors | Wong, Yick Fu., Chinese University of Hong Kong Graduate School. Division of Clinical and Pathological Sciences. |
| Publisher | Chinese University of Hong Kong |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, xii, 246 leaves : ill. ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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