Hydrophilic matrix tablets present a convenient method for oral modified drug delivery. The performance of such dosage forms is affected by multiple factors, amongst which the influence of tablet shape and structural properties have been partially investigated in previous literature. This work focused on investigating the influence of changing tablet properties on the in-vitro behaviour of hydrophilic matrix tablets, in particular, the influence of tablet face curvature on the hydration and drug release behaviour of round and elongated Xanthan Gum tablets containing the two model drugs Orphenadrine Citrate and Orphenadrine Hydrochloride. The influences of tablet overall porosity and of the formulation used on tablet behaviour were also investigated, in addition to the investigation of any interactions between the influences of tablet and formulation variables. Initially the properties of the powders incorporated into the various formulations used were characterised. The physical properties of the dry tablets were then investigated in terms of tablet tensile strength and Abstract 2 structural properties. The hydration behaviour of the various tablets was investigated quantitatively using live in-situ swelling studies and qualitatively using rheological and calorimetric methods. Finally the process of drug and polymer dissolution from the tablets was investigated. The results of the work indicated that tablet face curvature had a significant influence on the physical properties of the dry tablets as well as on the hydration and dissolution patterns associated with the hydrated tablets. The influence of tablet overall porosity was profound on the properties of the dry tablets but became rather minor upon tablet hydration. The type of formulation had a major influence on the properties of dry tablets. Moreover, ionic interactions between the two drugs and Xanthan Gum had a significant influence on the properties of hydrated tablets. Thus, tablet face curvature, porosity of the tablets and physicochemical properties of the drugs need to be considered when formulating a hydrophilic matrix tablet.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:441646 |
| Date | January 2007 |
| Creators | Muti, Emad Al |
| Publisher | University of Sunderland |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://sure.sunderland.ac.uk/3788/ |
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