Yes / The growth of cocrystalline phases continues to expand as a key area of crystal engineering research. Understanding the phase behavior of the material and controlling the crystalline form of the material from a solution-based route can be aided by the construction of a ternary phase diagram for the system. A range of methods exist for this process which display a variety of costs and time to achieve the final diagram. The application of quantitative NMR (qNMR) to this problem offers a fast analysis method to directly determine the solution composition of all species (coformers and solvent) and is demonstrated to successfully allow the construction of ternary diagrams with and without a cocrystal phase being formed for systems with high and low solubility.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18952 |
| Date | 01 May 2022 |
| Creators | Telford, Richard, Obule, Whitney, Seaton, Colin C. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2022 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.1c01311, Unspecified |
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