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An Investigation into the Effect of Backbone Amide Linker Position on the Solid Phase Peptide Synthesis of a Cyclic Pentapeptide

<p dir="ltr">A study on the impact of the position of the attachment of the photolabile, backbone amide linker, 4-formyl-3-hydroxy-5-nitrobenzoic acid, on the synthesis of a model cyclic pentapeptide was conducted. The peptide was synthesized on a solid support and cleaved photolytically. The crude product was analyzed for the effect of changing position by LC/MS, 1HNMR, and yield. The target peptide could not be identified convincingly by LC/MS or NMR. It was observed that attachment of the backbone amide linker to the N alpha of tyrosine provided the highest crude product yield.</p>

  1. 10.25394/pgs.24729585.v1
Identiferoai:union.ndltd.org:purdue.edu/oai:figshare.com:article/24729585
Date05 December 2023
CreatorsKhalil Castillo-Aponte (17551896)
Source SetsPurdue University
Detected LanguageEnglish
TypeText, Thesis
RightsCC BY 4.0
Relationhttps://figshare.com/articles/thesis/An_Investigation_into_the_Effect_of_Backbone_Amide_Linker_Position_on_the_Solid_Phase_Peptide_Synthesis_of_a_Cyclic_Pentapeptide/24729585

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