Inositols belong to an important class of biologically active compounds, named as
cyclitols (cyclic polyols), which have attributed high interest in the past decade due
to the glycosidase inhbition property that affects many biological processes.
Initially, 1,3,3a,7a-tetrahydro-2-benzofuran (69) was synthesized as a key compound
to synthesize bishomo-inositol derivatives. Then photooxygenation and
manganese(III) acetate oxidation reactions of this key compound were studied in
order to obtain isomeric inositol derivatives. Moreover, dihydroxylation and acid
catalyzed ring opening reactions were investigated. Finally, new synthetic
approaches for the synthesis of bishomo-inositol derivatives have been developed. In
addition to that whole products were conscientiously purified and characterized and
mechanism for the formation of the products has been discussed.
Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12613735/index.pdf |
Date | 01 October 2011 |
Creators | Bekarlar, Merve Gokcen |
Contributors | Balci, Metin |
Publisher | METU |
Source Sets | Middle East Technical Univ. |
Language | English |
Detected Language | English |
Type | M.S. Thesis |
Format | text/pdf |
Rights | To liberate the content for public access |
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