Photodynamic therapy (PDT) employs photosensitizing drugs for treating cancer. Once introduced into the body and localized in tumor cells, these photosensitizers are irradiated with light to produce active singlet oxygen radicals which kill cancer cells. The current drugs used in PDT have low quantum yield and always require a high energy radiation (normally laser). There is always a need for more effective drugs that have a high quantum yield and can be activated by visible light, in order to eliminate side effects caused by laser radiations.
In this work we synthesized derivatives of phenothiazine and phenothiazinium chromophores from the commercially available phenothiazine (1). These derivatives include: 3,7-dibromophenothiazinium perbromide (2), N-acetyl phenothiazine (5), N-acetyl-3,7-dibromophenothiazine (6), 3,7-dinitrophenothiazine (10), N-acetyl-3,7-dinitrophenothiazine (11), N-acetyl-3,7-diaminophenothiazine (12), thionine chloride (15) and 3,7-phenothiaziniumdinitrile (14). Synthesis of 3,7-phenothiazinium dicarboxylic acid was attempted using 1 and 15 as starting materials by exploring various synthetic routes for carboxylic acids.
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etd-3941 |
| Date | 01 August 2015 |
| Creators | Fanah, Selorm J |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Electronic Theses and Dissertations |
| Rights | Copyright by the authors. |
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