My thesis is organized as follows. First, I introduce a general overview on the nature of real proteins. Then I address the thermodynamics of proteins and how one can model it. After that I introduce a microscopic model for proteins and I discuss the reasons for its construction. After a thorough theoretical investigation of this model I make several predictions for its thermodynamic and dynamic behavior. I then introduce a dynamics for protein folding, including a master equation approach for the description of protein kinetics. Using the protein thermodynamics introduced earlier I implement some extensive Monte-Carlo computer calculation to elucidate the non Arrhenius modes in the protein folding. A mesoscopic model of the hierarchically constrained dynamics will be introduced after that to account for the observed behavior. Finally, I investigate an abstract but exactly solvable model which could serve as a cornerstone for the dream of protein designers---an ultimately fast folding protein. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.20287 |
| Date | January 1997 |
| Creators | Skorobogatiy, Maksim. |
| Contributors | Guo, Hong (advisor), Zuckerman, Martin (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001608882, proquestno: MQ44280, Theses scanned by UMI/ProQuest. |
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