We examine tracer diffusion in lipid bilayer membranes containing either cholesterol or lanosterol, using a random lattice Ising model. Specifically the model is a two-state off lattice tethered network of hard disks which is dynamically triangulated and the interactions between the hard disks are only effective along the tethers linking the disks. The model was already applied to lipid-sterol systems and was successful in reproducing the phase diagrams and related physical properties. In this thesis we apply this model in conjunction with Monte Carlo simulation methods as follows. We calculate the diffusion constant for lipid-cholesterol and lipid-lanosterol bilayer membranes both as function of temperature and sterol concentration in all accessible regions of the relevant phase diagrams. Comparison with experiment and comments on sterol related evolution are included.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.30776 |
| Date | January 2000 |
| Creators | Zhu, Hong, 1975- |
| Contributors | Zuckermann, Martin J. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001746358, proquestno: MQ64487, Theses scanned by UMI/ProQuest. |
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