Although the first experimental demonstration of neuromuscular transmission was made in the second century A. D. by Galen (see Fulton 1926, chapter 1) the highly specialized nature of the neuromuscular junction remained unknown until the middle of the nineteenth century. Then in 1847 Wagner (see Couteaux 1960) discovered that motor nerve terminals, unlike their parent axons, are unmyelinated, and later work by Kuhne (1888) revealed that they lie in invaginations of the muscle fibre surface. The finding of Sokolow (1874) that chronic denervation causes motor nerve terminal degeneration and disappearance without affecting muscle fibre structure further illustrated structural specificity by suggesting a discontinuity between motor nerve terminal and muscle fibre. [...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.117573 |
| Date | January 1965 |
| Creators | Cohen, M. W. |
| Contributors | Birks, R. (Supervisor), MacIntosh, F. C., Martin, K. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Physiology. ) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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