The purpose of this study was to investigate a) PTTG expression in pituitary adenoma subtypes, b) the correlation between PTTG expression and clinico-pathological variables in patients with Cushing’s disease with ACTH secreting pituitary adenomas, and c) PTTG expression in brain tumour subtypes. PTTG expression was investigated in 89 pituitary and 88 brain tumours, and 54 ACTH adenomas of patients with Cushing’s disease. Our results show that PTTG is expressed in the cytoplasm of pituitary adenoma cells, and at higher levels in GH adenomas, with lower PTTG expression levels being exhibited by PRL adenomas. Significant differences were noted between PTTG expression in medically treated and non-treated GH adenomas. However, PTTG expression in ACTH adenomas did not correlate with clinico-pathological variables, making it an unsuitable prognostic indicator in such tumours. In brain neoplasms, PTTG was expressed at higher levels in malignant tumours, whereas in less aggressive tumours, PTTG expression was considerably lower.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/18868 |
| Date | 15 February 2010 |
| Creators | Salehi, Fateme |
| Contributors | Cusimano, Michael, Kalman, Kovacs |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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