En el presente trabajo de investigación se evaluó el efecto antiinflamatorio y cicatrizante del extracto etanólico de hojas de Senna reticulata (Willd.)H.Irwin and Barneby “Retama” procedente del Departamento de San Martín (Tarapoto). Se determinaron los metabolitos secundarios mediante la marcha fitoquímica, identificando flavonoides, alcaloides, taninos, saponinas y glicósidos. Luego se efectuó el screening cromatográfico, para posteriormente realizar las lecturas al espectrofotómetro.
Para la investigación farmacológica se preparó una crema base cold-cream a la cual se le añadió concentraciones de 5%, 10% y 20% del extracto, realizando el estudio antiinflamatorio y cicatrizante en ratones albinos de 25 a 30 g. Comparándose con Diclofenaco al 1% en gel para el efecto antiinflamatorio dando resultados no significativos. Mostró acción cicatrizante significativa confrontando con Neomicina-Bacitracina, glicina, L- cisteina, DL – treonina; obteniendo mayor efecto con la crema al 20% luego la crema al 10% y la crema al 5% del extracto etanólico. / In the present thesis there was evaluated the antiinflammatory and healing effect of the extract etanolic of leaves of Senna reticulata (Willd.) H Irwin and Barneby “Broom” proceeding from the departament of San Martín (Tarapoto). The secundary metabolitos were identified by phytochemistry procedure identifying flavonoids, alkaloids, tannins, saponines and glicosides. Then the chromatographic screening was effected later to realize the readings to the spectrophotometer.
For the pharmacological investigation a cream was prepared base cold-cream to which were added concentrations of 5%, 10% and 20% of the extract, realizing the antiinflammatory and healing study in albino mice from 25 to 30 g. being compared by Diclofenaco to 1% in gel for the antiinflammatory effect giving not significant results. Showed healing significant action bordering with Neomicine – Bacitracine, glicine, L-cisteine, DL –treonine; obtaining major effect with the cream to 20% then the cream to 10% and the cream to 5% of the extract etanolic.
| Identifer | oai:union.ndltd.org:Cybertesis/oai:cybertesis.unmsm.edu.pe:cybertesis/2585 |
| Date | January 2007 |
| Creators | Vargas Carbajal, Carlos Javier |
| Publisher | Universidad Nacional Mayor de San Marcos |
| Source Sets | Universidad Nacional Mayor de San Marcos - SISBIB PERU |
| Language | Spanish |
| Detected Language | English |
| Type | info:eu-repo/semantics/bacherlorThesis |
| Source | Universidad Nacional Mayor de San Marcos, Repositorio de Tesis - UNMSM |
| Rights | info:eu-repo/semantics/openAccess |
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