Return to search

Blood Filtration for Multiplexed Point-of-care Diagnostic Devices

In the developing world, there are large populations suffering from infectious diseases, many of whom are located in remote regions. With the rapid growth in microfluidic systems in recent years, complex functions of conventional diagnostic equipment have been miniaturized and integrated into small devices at the size of a credit card (so-called portable Point-of-care (POC) devices).
In this thesis a novel approach to overcoming the challenge of in-field biological sample processing and preparation to produce high quality fluids that can be readily used for downstream testings is described and proof of concept experiments presented. This approach uses hydrodynamic effects and combines nanoporous membrane with microfluidic systems and to filter the cellular component of blood. Experiments presented here demonstrate successful cells filtration from whole blood. Employing hydrodynamic effects is also shown to be an effective and potentially useful technique to isolate cells and plasma within appropriate micro-architectures.

Identiferoai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33674
Date29 November 2012
CreatorsPham, Ngoc Minh
ContributorsSinton, David
Source SetsUniversity of Toronto
Languageen_ca
Detected LanguageEnglish
TypeThesis

Page generated in 0.0019 seconds