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Synthesis of peptide-loaded chitosan nanoparticles for the treatment of sexually transmitted infections (STI’s)

>Magister Scientiae - MSc / Peptides are among the main drugs which attract much attention because of their great potential
in treating sexually transmitted diseases and other chronic diseases. There has been a major
challenge of delivering these drugs in mucosal sites with low pH environment. The aim of this
study is to synthesize acidic pH stable peptide loaded chitosan nanoparticles gels that could
penetrate mucus layers covering the epithelial cells and kill HIV virus. Chitosan nanoparticles
were synthesized by crosslinking method called Ionic gelation with Sodium
tripolyphosphateTPP. / 2023

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/7726
Date January 2019
CreatorsPhathekile, Bonke
ContributorsOnani, Martin, Meyer, Mervin, Okuthe, Emily. G
PublisherUniversity of Western Cape
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
RightsUniversity of Western Cape

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