Putrescine, spermidine and spermine are classified as polyamines and are found in virtually all living tissues. Although polyamines have been proposed to influence cell proliferation and differentiation, the mechanism by which they do so is not well understood. Previous studies in our laboratory have been focused on the interconversion of spermidine and N8-acetylspermidine (N8-AcSpd) and the enzyme N8-AcSpd deacetylase. In the present study, a N8-AcSpd deacetylase inhibitor, 7-[N-(3-aminopropyl) amino] heptan-2-one (APAH) was employed to study the effect of N8-AcSpd deacetylase inhibition on proliferation of cultured cells.
This study for the first time shows the pharmacological effects of elevated N8-AcSpd levels and inhibition of N8-AcSpd deacetylation. Based on the fact that inhibition of N8-AcSpd deacetylation stimulates the growth of cells in culture, we propose to search for a new class of antitumor agents among the inhibitors of spermidine N8-acetyltransferase.
| Identifer | oai:union.ndltd.org:pacific.edu/oai:scholarlycommons.pacific.edu:uop_etds-3240 |
| Date | 01 January 1992 |
| Creators | Wang, Zaijie |
| Publisher | Scholarly Commons |
| Source Sets | University of the Pacific |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | University of the Pacific Theses and Dissertations |
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