Introduction: Older persons usually suffer from multiple chronic disorders and consequently use more medications than younger adults and often polypharmacy. Polypharmacy is, unfortunately, one of the risk factors for negative outcomes in the old age. The aim of this diploma thesis was to summarize by narrative literature review the negative outcomes of polypharmacy in older adults documented in pharmacoepidemological studies published between 2005 and 2015 years. The outputs of this diploma thesis create part of results of the research subgroup "Aging and Changes in the Therapeutic Value of Medications in the Aged" (Department of Social and Clinical Pharmacy, Faculty of Pharmacy, Charles Univerzity) and the EU COST Action initiative IS1402 (2015-2018). Methods: Using datasets of Web of Science, PubMed and Embase, the narrative literature review was conducted in the period 2014 - 2015, in which we summarized outcome studies dealing with negative outcomes of polypharmacy in older patients published between 2005- 2015 years. Key words for the literature review were: "seniors, older patients, elderly, older age, polypharmacy, polymedication, multiple drug use, negative outcomes, impact, hospitalization, mortality, averse reactions, averse drug events, costs, expenditures. We identified 563 studies...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:356241 |
| Date | January 2017 |
| Creators | Fidranský, Filip |
| Contributors | Fialová, Daniela, Thomson, Petra |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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