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An Investigation on Hydration with N-acetylcysteine and Sodium Bicarbonate for Prevention of Contrast-Induced Nephropathy

Class of 2010 Abstract / OBJECTIVES: The purpose of this study was to determine the incidence of contrast induced nephropathy (CIN) for patients receiving a pre-hydration regimen to prevent CIN.
METHODS: This was a descriptive retrospective chart review study. Charts were reviewed from Banner Boswell Medical Center and a nephrologist’s office in Sun City, Arizona.
RESULTS: There were a total of 12 patients included in the study. The population after completetion of chart reviews consisted of 6 male patients and 6 female patients. The age range of the patients included was 54-90 years old. CIN occurred in zero of the twelve patients. Half of the 12 patients had a decrease in serum creatinine ranging from 0.1- 0.6 mg/dL, 24-48 hours post-diagnostic procedure.
CONCLUSIONS: There was no incidence of CIN after the 12 patients received the specific protocol. This study demonstrates the potential for this regimen as a pre-hydration option for individuals undergoing procedures in which radiocontrast is necessitated. A prospective observational study with a larger sample size would be warranted to determine the safety and efficacy of the protocol and increase the validity of the results of this descriptive study.

Identiferoai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/623902
Date January 2010
CreatorsRodriguez, Tamara
ContributorsNolan, Paul, College of Pharmacy, The University of Arizona
PublisherThe University of Arizona.
Source SetsUniversity of Arizona
Languageen_US
Detected LanguageEnglish
Typetext, Electronic Report
RightsCopyright © is held by the author.

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