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Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease

Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:27800
Date January 2012
CreatorsLinning, Philipp, Haussmann, Ute, Beyer, Isaak, Weidlich, Sebastian, Schieb, Heinke, Wiltfang, Jens, Klafki, Hans-Wolfgang, Knölker, Hans-Joachim
PublisherRoyal Society of Chemistry
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:article, info:eu-repo/semantics/article, doc-type:Text
SourceOrganic & biomolecular chemistry 2012;10:8216–8235, ISSN: 1477-0520
Rightsinfo:eu-repo/semantics/openAccess
Relation10.1039/c2ob26103k

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