Faculty of Health Sciences
School of Patholgy
8601804k
erine.gregersen@nhls.ac.za / The oral anticoagulant, warfarin, when administered in pregnancy, can cause warfarin
embryopathy, fetal central nervous system abnormalities, spontaneous abortion and fetal
intrauterine death. Women with prosthetic heart valves usually require warfarin in pregnancy
because of their high risk for thromboembolic complications. Anticoagulation regimens in
pregnancy in these women aim to balance the fetal effects of warfarin with maternal risks of
thromboembolism.
This study was conducted by structured interview of 124 black urban South African women
of childbearing age, who had at least one warfarin-exposed pregnancy. The study aimed to
determine the pregnancy outcomes in this cohort, their awareness of the effects of warfarin in
pregnancy, and what management practices, as reported by them, had occurred with regard to
their anticoagulation in pregnancy and what genetic counselling they had received. There was
a significant difference in outcome between warfarin-exposed and non-exposed pregnancies;
55.2% (123/223) of warfarin-exposed pregnancies ended in the birth of an abnormal baby,
spontaneous abortion or intrauterine death. The warfarin embryopathy rate was estimated at
4.5 – 5.4%. Most women reported having been given information about warfarin in
pregnancy, though their awareness about the personal and fetal effects of warfarin was often
inaccurate. Of warfarin-exposed pregnancies, 95% were reportedly exposed during critical
weeks six to ten of pregnancy, and >50% after 36 weeks. Only 5/124 (4%) interviewees had
genetic counselling. Poor pregnancy outcomes, lack of awareness about the effects of
warfarin in pregnancy, and management practices at odds with international regimens are all
areas highlighted by this study that require urgent attention in this high-risk group of women.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/1838 |
| Date | 17 November 2006 |
| Creators | Gregersen, Nerine Evelyn |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 88811 bytes, 71592 bytes, 88891 bytes, 129578 bytes, 141208 bytes, 72091 bytes, 159722 bytes, 32848 bytes, 90437 bytes, 50820 bytes, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf |
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