no / Two new prenylated flavanones, 2S-3¿-(2-hydroxy-3-methylbut-3-enyl)licoflavone-4¿-methyl ether (3) and 2S-3¿-(2-
hydroxy-3-methylbut-3-enyl)abyssinone II (4), and four known flavanones (1, 2, 5, 6) were isolated from the stem bark
of Erythrina addisoniae. The structures were elucidated on the basis of their spectroscopic and physicochemical data.
None of the compounds showed antioxidative properties. 4¿-Methylabyssinone V (1) and abyssinoflavanone VII (6)
showed moderate cytotoxic activity (IC50 ) 5 and 3.5 ¿mol/L, respectively), but apoptosis (caspase-3/7-activation,
nuclear fragmentation) was selectively induced by abyssinoflavanone VII (6).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4532 |
| Date | January 2008 |
| Creators | Watjen, W., Suckow-Schnitker, A-K., Rohrig, R., Kulawik, A., Addae-Kyereme, Jonathan A., Wright, Colin W., Passreiter, C.M. |
| Publisher | American Chemical Society |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, published version paper |
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