Ectopic expression of TAL-1 increases resistance to TNF[alpha]-induced apoptosis in Jurkat cells via changes in the NF-kB signaling pathway / Ectopic expression of T-cell acute lymphoblastic leukemia 1 increases resistance to tumor necrosis factor [alpha]-induced apoptosis in Jurkat cells via changes in the nuclear factor kappa B signaling pathway

Description

TAL-1, ectopically expressed in 60% of T-cell acute lymphoblastic leukemia (T-ALL) patients, may contribute to poor chemotherapy response. This research sought to determine if TAL-1 influences expression of proteins involved in the NF-kB signaling pathway and thus, resistance to cell death. NF-kB, IKKy, and TRAF-2 expression levels were found to be TAL-1 dependent. Cell death levels were higher in staurosporine-treated cells compared to tumor necrosis factor a-treated or dual-treated cells. TAL-1, NF-kB, IKKy, and TRAF-2 expression levels were elevated in tumor necrosis factor a-treated cells and reduced in staurosporine-treated or dual treated cells compared to untreated cells. These results suggest TAL-1 influences expression of proteins involved in the NF-kB signaling pathway, thus inducing an anti-apoptotic response in the cell. / Department of Biology

Links & Downloads

1. http://cardinalscholar.bsu.edu/handle/123456789/194751
2. http://liblink.bsu.edu/uhtbin/catkey/1642170

Tags

Lymphoblastic leukemia--Genetic aspects.

Tumor necrosis factor--Receptors.

NF-kappa B (DNA-binding protein)

Apoptosis.

Protein kinases--Inhibitors.

Additional Fields

Identifer	oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:123456789/194751
Date	09 July 2011
Creators	Lucas, Bethany R.
Contributors	Olesen, James B.
Source Sets	Ball State University
Detected Language	English