by Li Leung Wah. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1993. / Includes bibliographical references (leaves 76-81). / Acknowledgements / Abstract / Chapter 1. --- Protein modeling --- p.1 / Chapter 1.1 --- Genetic Engineering --- p.1 / Chapter 1.2 --- Protein Engineering --- p.2 / Chapter 1.2.1 --- The basic concept --- p.2 / Chapter 1.2.2 --- The importance of protein modeling --- p.3 / Chapter 1.2.3 --- Applications --- p.4 / Chapter 1.2.3.1 --- Industry --- p.4 / Chapter 1.2.3.2 --- Medicine --- p.4 / Chapter 1.3 --- The structure of protein molecule --- p.5 / Chapter 2. --- About this thesis --- p.8 / Chapter 2.1 --- Methods on protein tertiary structure prediction --- p.8 / Chapter 2.1.1 --- Energy minimization method --- p.9 / Chapter 2.1.2 --- Sequence homology method --- p.9 / Chapter 2.1.3 --- Hierarchical assembly method --- p.11 / Chapter 2.2 --- Artificial Intelligence and molecular modeling --- p.11 / Chapter 2.3 --- Computer graphics and molecule display --- p.13 / Chapter 2.3.1 --- Molecular model in computer graphics --- p.13 / Chapter 2.3.2 --- Interactive graphic operations --- p.16 / Chapter 2.4 --- The objective of this thesis --- p.17 / Chapter 3. --- Algorithms for protein secondary structure prediction --- p.20 / Chapter 3.1 --- Hydrophobicity --- p.20 / Chapter 3.2 --- Algorithms for protein secondary structure prediction --- p.22 / Chapter 3.2.1 --- The Chou and Fasman method --- p.23 / Chapter 3.2.1.1 --- Method --- p.24 / Chapter 3.2.1.2 --- Results --- p.25 / Chapter 3.2.2 --- The GOR method --- p.26 / Chapter 3.2.2.1 --- Theory --- p.26 / Chapter 3.2.2.2 --- Method and results --- p.26 / Chapter 3.3 --- A proposed algorithm --- p.28 / Chapter 3.3.1 --- Procedure of our algorithm --- p.30 / Chapter 4. --- A protein tertiary structure prediction method --- p.31 / Chapter 4.1 --- The linkage between two amino acids --- p.32 / Chapter 4.2 --- Rotation angle between two peptide planes --- p.34 / Chapter 4.2.1 --- Helical structure --- p.35 / Chapter 4.2.1.1 --- Concept --- p.35 / Chapter 4.2.1.2 --- Procedure --- p.36 / Chapter 4.2.2 --- Sheet structure --- p.37 / Chapter 4.2.3 --- Turn structure --- p.38 / Chapter 4.2.4 --- Anti-parallel sheet and turn structure --- p.40 / Chapter 4.3 --- Random factor in rotation angle of peptide planes --- p.41 / Chapter 4.4 --- Atomic size --- p.41 / Chapter 4.5 --- Tertiary structure prediction algorithm --- p.42 / Chapter 5. --- Implementation --- p.45 / Chapter 5.1 --- Hardware --- p.45 / Chapter 5.2 --- User-defined data types and data structures --- p.46 / Chapter 5.3 --- Technique in molecule displaying --- p.48 / Chapter 5.4 --- Image processing --- p.50 / Chapter 5.5 --- Options in our program --- p.52 / Chapter 5.6 --- Steps in protein tertiary structure prediction --- p.54 / Chapter 6. --- Results --- p.59 / Chapter 6.1 --- The results of protein secondary structure prediction --- p.59 / Chapter 6.2 --- The results of protein tertiary structure prediction --- p.66 / Chapter 7. --- Conclusion --- p.70 / Chapter 7.1 --- Comments on protein secondary structure prediction algorithm --- p.70 / Chapter 7.1.1 --- Advantages and disadvantages --- p.70 / Chapter 7.1.2 --- Further development --- p.71 / Chapter 7.2 --- Discussion on X-ray crystallographic data --- p.72 / Chapter 7.3 --- Comments on the protein tertiary structure prediction algorithm --- p.73 / Chapter 7.3.1 --- Advantages and disadvantages --- p.73 / Chapter 7.3.2 --- Further development --- p.74 / Chapter 7.3.2.1 --- Rotation angle between two peptide planes --- p.74 / Reference --- p.76 / Glossary --- p.82 / Appendix A An algorithm to determine hydrophobic value --- p.83 / Appendix B Chou and Fasman algorithm --- p.84 / Appendix C GOR algorithm --- p.87 / Appendix D Shading algorithm --- p.88
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_319203 |
| Date | January 1993 |
| Contributors | Li, Leung Wah., Chinese University of Hong Kong Graduate School. Division of Computer Science. |
| Publisher | Chinese University of Hong Kong |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, [ii], 89 leaves : ill. (some col. mounted) ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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