The efferent projections of the Cat's dorsal nucleus of the lateral lemniscus (DLL) were examined first with kainic acid-induced anterograde degeneration and $\sp3$H-leucine autoradiography, then by systematic repetition of horseradish peroxidase and fluorescent dye retrograde tract-tracing techniques. Biochemical properties of DLL neurons and their projections were studied first by immunohistochemical methods using antibodies directed against GABA and glycine, then by retrograde transport of $\sp3$H-GABA and $\sp3$H-glycine. / The results show that DLL projects axons to the ipsilateral inferior colliculus, and projects axons through the commissure of Probst to contralateral inferior colliculus and contralateral DLL. Approximately half of DLL projections to contralateral structures (IC and DLL) arise from axon collaterals. DLL's ipsilateral and contralateral projections are topographically and tonotopically organized. / Immunohistochemical studies show a large proportion (61-83%) of DLL neurons are immunolabeled by antibodies to GABA, few by antibodies to glycine. Furthermore, DLL neurons retrogradely transport $\sp3$H-GABA but not $\sp3$H-glycine from injections into the inferior colliculus. / The results also show that the commissure of Probst originates primarily (80%) from DLL, the remainder (20%) originates from nucleus sagulum. Orthograde transport studies show the nucleus sagulum projects to the inferior colliculus and medial geniculate body bilaterally, and to the nucleus sagulum of the opposite side. / Source: Dissertation Abstracts International, Volume: 49-08, Section: B, page: 3496. / Major Professor: Karen Kircher Glendenning. / Thesis (Ph.D.)--The Florida State University, 1988.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_77839 |
| Contributors | Hutson, Kendall Alan., Florida State University |
| Source Sets | Florida State University |
| Language | English |
| Detected Language | English |
| Type | Text |
| Format | 173 p. |
| Rights | On campus use only. |
| Relation | Dissertation Abstracts International |
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