Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.

Description

Some compounds, analogous to those found in naturally
occurring systems, are found to possess chemotherapeutic activity.
Some, in the form of their nucleoside or nucleotide derivatives,
are valuable antimetabolites in that they may block normal RNA
or DNA polymerisation, or may be incorporated into nucleic acids
to form fraudulent, but not necessarily defective, polymers.
Modification of natural ring systems, with a view to promoting
chemotherapeutic activity is therefore of considerable interest;
variation in the position and nature of the modification or ring
substituent having a marked effect on chemotherapeutic activity.
It is the purpose of this thesis to suggest methods for the
facile synthesis of various uracils, pyrazoles and pyrazolo
[3,4-d]
-
pyrimidines with alkyl, aryl and glycosyl substituents such that
the nature of the ring substituents is easily varied.
To this end a number of ethoxymethylene reagents were prepared
which, by reaction with primary amines and hydrazines, would give
acyclic intermediates capable of easy cyclisation into the uracil,
pyrazole and pyrazolo
[3,4-d]
pyrimidine ring systems. Variation in
the nature of specific substituents being determined by the choice
of amine or hydrazine, other substituents being varied by modification
of the original reagent. / S.R.G.

Links & Downloads

1. http://hdl.handle.net/10454/4400

Tags

Pyrimidines

Imidazoles

Purines

Chemical synthesis

Pyrazoles

Pyrazolo pyrimidines

Chemotherapeutic activity

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4400
Date	January 1978
Creators	Hildick, Brian G.
Contributors	Shaw, G.
Publisher	University of Bradford, Board of Physical Sciences
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Thesis, doctoral, PhD
Rights	<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.