Magnetic Resonance Spectroscopy is a powerful non-invasive tool for investigating liver metabolism in vivo. PRESS and STEAM localized 1H MRS can be used to provide liver lipid measurements calculated from the fat to water peak ratios. Surface coils can also be used to measure other metabolites using multinuclear MRS, 13C MRS directly measures glycogen levels and 31PMRS measures ATP and other phosphate metabolites. This thesis reports on studies undertaken to develop these techniques and describes a number of in vivo investigations that explored the effects of dietary interventions on hepatic metabolism.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:706368 |
| Date | January 2014 |
| Creators | Bawden, Stephen |
| Publisher | University of Nottingham |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://eprints.nottingham.ac.uk/30390/ |
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