Herein it is presented a further development of the well-established catalytic asymmetric allylation of aldehydes leading to enantiopure homoallylic alcohols Stereogenic centre(s) served as the foundation for synthesis of a variety of other advanced intermediates and building blocks with multiple chiral centres - New approaches to homoallylic alcohols were dementrated with excellent control of chiral centers - Biologically relevant carbohydrate analogues were synthesised in four possible configurations using singlet oxygen raction as the key step - δ-hydroxy-β-amino acids were synthetised diastereoselectively using Pd catalysis as the key step. - A novel approach to synthesis of isoxazolidines and pyrazolidines was demonstrated.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:630949 |
| Date | January 2011 |
| Creators | Barlog, Maciej L. |
| Publisher | University of Glasgow |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://theses.gla.ac.uk/2815/ |
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