Modified cytidylic and adenylic acids have been synthesised and studied as possible inducers of interferon when hybridised with the appropriate polynucleotides. The report in this thesis describes: a) The synthesis and characterisation of poly (5-fluorocytidylic acid) to complete the series of 5-halo substituted cytidylic acids. Poly(I). poly(fl⁵C) was interferon inducing. b) The synthesis and characterisation of poly (5-dimethylaminocytidylic acid) in which a substituent other than the halogens was inserted into the 5-postion of cytidine. The polymer formed a 1:1 hybrid with poly(I) and the hybrid was a good inducer of interferon. c) The synthesis and characterisation of poly (8-oxyadenylic acid) which was one of the first 8-substituted homopolymers of adenosine.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:595013 |
| Date | January 1973 |
| Creators | Folayan, Joseph Ololade |
| Publisher | University of Warwick |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://wrap.warwick.ac.uk/73778/ |
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