A protocol for the analysis of preferential gene expression was devised and validated. Analysis revealed possible sequence upregulation of RNA polymerase beta subunits, pyruvate formate lyase activating enzyme and a deoxyglucose epimerase enzyme at pH 7.0. The colonisation patterns in all sites were shown to be complex with many different clonotypes of a given species present. Interestingly, over time the colonisation patterns were not stable with significant changes in the species representation. The Streptococcus anginosus group has been show to display a significant amount of genomic diversity during in-vitro culture.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:583382 |
| Date | January 2004 |
| Creators | Brown, Jonathon David |
| Publisher | Cardiff University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://orca.cf.ac.uk/54077/ |
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