The Arabidopsis HapMap project, and follow-on work carried out by the Bergelson and Nordborg groups, established in broad outline the demographic history and population structure of wild Arabidopsis thaliana. Genome‐wide association studies are likewise making considerable advances in identifying genes associated with ecologically significant traits, and thus in identifying candidate genes likely to be under the action of natural selection. The aim of this project has been to further expand and combine these lines of investigation, by using genomic data to test ecological hypotheses and to grant more complete insight into the rangeof selection pressures acting upon wildpopulations. A method to measure and elucidate the genetic similarity of genomic regions between sampled accessions was therefore developed to facilitate this. 250K SNP data from RegMap accessions was then examined for evidence of patterns of migration and gene flow across Europe. Those observations formed the basis of a simple model of the history of the UK population relative to that of Europe. Comparisons of observed genotypes against expectations derived from the modelallowed the identification of genomic regions under the influence of selection. Loci corresponding to signatures of selection indicated positive selection acting upon phenotypes of disease resistance, flowering time, and seed size.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:606156 |
| Date | January 2013 |
| Creators | Pearson, Neil |
| Publisher | University of Warwick |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://wrap.warwick.ac.uk/61699/ |
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