Moreover, significant differences were found in the ratio of FcγRIIb1/FcγRIIb2 expression between the cohorts of healthy controls and RA and SLE patients. The RA and SLE patients expressed relatively higher levels of the FcγRIIb2 isoform which promotes antigen-processing suggesting that these B cells may play some role in priming autoreactive responses in such individuals. Thus, as these inflammatory disorders constitute spectrum diseases, such defects in the regulation of B cell responses could be one of the contributing factors aggravating autoimmune disease development in some subgroups of patients.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:508003 |
| Date | January 2009 |
| Creators | Thalhamer, Theresa |
| Publisher | University of Glasgow |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://theses.gla.ac.uk/1375/ |
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