A series of novel multi-metallic luminescent Au(I) and Re(I) complexes have been synthesised targeting functionality as cellular imaging and/or therapeutic agents. Both the ligands and their complexes have been characterised by a variety of spectroscopic and spectrometric techniques. Several complexes were also characterised by X-ray crystal diffraction and/or elemental analysis. In both chapters two and three the modulation of the luminescent properties of a series of mono- and di-metallic [Re(CO)3(N^N)L]+ type complexes bearing functionalised alkyl chains by hydrophobically driven, intra- and intermolecular conformational changes is reported. Additionally, the first application of di-metallic Re(I) complexes in cellular imaging is reported with specific localisation in the nucleoli or ER and Golgi apparatus. In both chapters four and five the synthesis of novel mono- and di-metallic Au(I) complexes is reported. Several complexes demonstrated cytotoxicity as well as compartemental localisation in cellular imaging demonstrating their potential as dual-functional cellular imaging and/or therapeutic agents. As an extension to the work discussed in Chapters two to five, the synthesis of novel multi-metallic luminescent complexes is reported in Chapter six. For the tri-hetero-metallic complex incorporating Au(I) and Re(I) units, cytotoxicity towards four cancer cell lines and non-specific localization throughout the entire cell is described.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:567485 |
| Date | January 2012 |
| Creators | Balasingham, Rebeca Glory |
| Publisher | Cardiff University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://orca.cf.ac.uk/43088/ |
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