By asymmetric transfer hydrogenation, substituted quinolines, which are generally regarded as challenging substrates for reduction, were successfully converted into tetrahydroquinolines using "tethered" Ru(II) and "tethered" Rh(III) complexes in formic acid/triethylamine. An ether-linked "tethered" catalyst was successfully synthesized through a sequence that avoids the use of a Birch reduction for the formation of a 1,4-cyclohexadiene moiety. The ether link is incorporated between the basic amine of the ligand and the η6- arene ring, giving results comparable to the alkyl-"tethered" complexes. N-alkylated complexes containing a straight-chain substituent attached to a hydroxyl, ether or ester function can act as effective catalysts for the reduction of ketones, and also contains the required functionality for attachment of the catalyst to a heterogeneous support.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:560101 |
| Date | January 2011 |
| Creators | Parekh, Vimal |
| Publisher | University of Warwick |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://wrap.warwick.ac.uk/45754/ |
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