Aim: Investigated the use of granulated sugar in the management of sloughy, necrotic and infected exuding wounds. Method: The investigation followed the Medical Research Council (MRC, 2007) framework for investigation of complex interventions. Pre-clinical: The study was registered with MHRA, followed by development and design of the mode of sugar delivery to patient use. Evidence review: A systematic review and meta-analysis concluded that there was no existing good quality evidence to support the routine use of sugar dressings. Phase I: Laboratory studies found that all three sugars showed relatively equal activity against all the bacteria tested although Demerara sugar was slightly less active. Phase II: A feasibility study of 22 patients concluded that both insulin and non-insulin treated diabetic patients can be treated with sugar dressing without affecting their blood sugar levels. Phase III: A randomised controlled trial failed to recruit the intended numbers and final analysis was carried out on 22 patients randomised to sugar and 19 randomised to usual care. 19 (86%) achieved debridement at 4 weeks in the sugar group compared to 6 (32%) standard care group (Fisher’s exact test: p<0.001). Overall conclusion: Sugar has an effect on micro-organisms and can be used in modern hospitals and community settings.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:646172 |
| Date | January 2015 |
| Creators | Murandu, Moses Donald |
| Publisher | University of Birmingham |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://etheses.bham.ac.uk//id/eprint/5793/ |
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