The toxicological investigations demonstrated quite clearly the different toxicological properties of the MA, CRS and ANR. The CRS proved to be fibrogenic in rat lung with a 5.0mg single instillation dose after long-term (1 year) exposure whereas ANR was minimally bioreactive. The MA did not cause inflammation in the lung until 49 weeks post-instillation even though size augmentation with granuloma formation in thoracic lymph nodes were recognised at 13 weeks. These findings suggested that the size and granuloma formation of thoracic lymph nodes were good early markers to assess the toxicity of crystalline silica containing volcanic ash. Histopathological and physicochemical investigations confirmed that the particles drained from the lung were deposited in mainly the granulomatous areas in the nodes. Furthermore, the crystalline silica content of the MA in the nodes was greater than that noted in the MA in the lung tissue and the original instillate. The macroarray technology has provided additional information on MA and CRS induced inflammation. A number of candidate inflammatory markers were identified
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:583418 |
| Date | January 2004 |
| Creators | Lee, Sang Hee |
| Publisher | Cardiff University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://orca.cf.ac.uk/55387/ |
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