Masters Research - Masters of Philosophy / INTRODUCTION: Level III dosimetric intercomparison studies test the entire radiotherapy patient treatment chain from diagnostic imaging to treatment delivery and verification imaging at multiple radiotherapy centres. The anthropomorphic phantom employed in an intercomparison needs to meet specific criteria including portability, tissue equivalence and accommodation of radiation detectors to ensure clinical relevance and dosimetric accuracy. The proposition that a purpose-built phantom can encompass all the attributes necessary for precise Level III dosimetric intercomparisons for prostate cancer is the premise of this body of work. METHODS: Organ outlines were generated from a human computed tomography image set and incorporated into the phantom design to replicate human anatomy as closely as possible. Twenty-five points of interest were located throughout the dataset to identify where point-dose values could be measured with thermoluminescence dosimeters. The centre of the prostate was identified as the location for measurement with a small-volume ionization chamber. The materials used in this phantom were tested against water to determine relative attenuation, density and Hounsfield Units. Three materials were chosen to mimic bone, organs, and a backfill material and the phantom was manufactured using modern prototyping techniques into five separate coronal slices. Time lines and resource requirements for the phantom design and manufacture were recorded. The ability of the phantom to mimic the entire treatment chain was tested at the Calvary Mater Newcastle Hospital. RESULTS: The phantom CT images indicated the densities and organ geometries were comparable to the original patient. The phantom proved simple to load for dosimetry and rapid to assemble. Measurements indicated the reproducibility to be in the order of 1% for the ionization chamber measurement and within 3% for thermoluminescence dosimeters. Due to heat release during manufacture, small airgaps were present throughout the phantom producing artifacts on lateral images. The overall cost for production of the prototype phantom was comparable to other commercial anthropomorphic phantoms ($AU45,000). The phantom was shown to be suitable for use as a “patient” to mimic the entire treatment chain for typical external beam radiotherapy for prostate and rectal cancer. Outlining of relevant structures by a radiation oncologist was uncomplicated and the computerised treatment plan compared well with the dose measured using ionisation chambers and thermoluminescence dosimeters. DISCUSSION & CONCLUSIONS: The phantom constructed for the present study incorporates all characteristics necessary for accurate Level III intercomparison studies and will be an effective tool for an intercomparison of pelvic treatments in Australasia. These results may benefit analysis of outcomes for prostate cancer treatments, especially in the clinical trial environment. It will be of significant interest in the future to use the phantom to assess advanced radiotherapy delivery techniques such as Intensity Modulated Radiation Therapy (IMRT).
| Identifer | oai:union.ndltd.org:ADTP/280691 |
| Date | January 2009 |
| Creators | Harrison, Kristie |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
| Rights | Copyright 2009 Kristie Harrison |
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