Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide
exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation.
Although there is growing evidence to support the relationship between RCC1 and cancer, detailed
pancancer analyses have not yet been performed. In this genome database study, based on The
Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the
potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly
expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is
closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed
that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the
functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1
to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related
to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate
the association of RCC1 with the tumor mutation burden and microsatellite instability in various
tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor
immunology in various tumors and indicate its potential as marker for therapy prognosis and
targeted treatment strategies.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88569 |
| Date | 11 December 2023 |
| Creators | Wu, Changwu, Duan, Yingjuan, Gong, Siming, Kallendrusch, Sonja, Schopow, Nikolas, Osterhoff, Georg |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1422-0067, 10.3390/ijms22147374 |
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