Over the last decade, microfluidics has emerged as a distinct new field with promising applications for diverse research areas. The ability to precisely control fluids at the microscale allows the execution of a variety of programmable semi-automatic operations on the same device, effectively forming a lab-on-a-chip. In particular, droplet-based microfluidic systems – which reliably generate highly uniform microdroplets at a high throughput – enable the controlled compartmentalization of biological material and have the potential to influence mainstream biomedical research. In this thesis, a microfluidic platform is presented that allows the encapsulation of viable cells in agarose microcapsules for applications in cell–based therapy. As an improvement to pre-existing methods of cell encapsulation, the proposed system combines continuous high throughput cell-encapsulation with on-chip microcapsule gelation and purification.
| Identifer | oai:union.ndltd.org:uottawa.ca/oai:ruor.uottawa.ca:10393/31852 |
| Date | January 2014 |
| Creators | Monette-Catafard, Nicolas |
| Contributors | Godin, Michel |
| Publisher | Université d'Ottawa / University of Ottawa |
| Source Sets | Université d’Ottawa |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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