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Functionally non-adaptive retinal plasticity in rat models of human retinal degenerative disease

The established model used for evaluating potential therapies for retinal disease
has significant limitations. A new model is proposed to account for these limitations: the
visual adaptation model. The visual adaptation model was developed to provide a novel
approach for testing potential treatments for retinal disease, and the work in this thesis
provides empirical support for this model. Specifically, we evaluated two potential
therapies for retinal degenerative disease and examined their effects on vision and retinal
anatomy. In addition, the profile of retinal reorganization and its functional correlates
were examined in RCS rats and transgenic rats which express a rhodopsin mutation;
however, immunohistological work targeted one specific line (S334ter-4). Collectively,
these studies provide evidence that supports the retinal adaptation model. These studies
also provide a novel view of retinal and visual function in retinal disease which should be
considered when evaluating treatments involving retinal degeneration. / xvii, 205 leaves : ill. ; 29 cm. --

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:ALU.w.uleth.ca/dspace#10133/726
Date January 2008
CreatorsMcGill, Trevor, University of Lethbridge. Faculty of Arts and Science
ContributorsPrusky, Glen
PublisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, Arts and Science, Neuroscience
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
Languageen_US
Detected LanguageEnglish
TypeThesis
RelationThesis (University of Lethbridge. Faculty of Arts and Science)

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