A pathophysiological study was made of spontaneously breathing dogs anaesthetised by a neurolept-analgesic technique and exposed to 100% oxygen at 2 ATA to demonstrate the time-course and mechanism of response. The animals remained apparently normal for some 18 hours, following which the majority developed a fulminating intra-alveolar oedema and died of hypoxaemia within a few hours. There was no evidence of systemic nor pulmonary capillary hypertension, and electron microscopy demonstrated complete absence of damage to the endothelial and Type 1 epithelial cells of the alveolar septum. Changes were detected in the Type 2 cells, and oedemagenesis was attributed to an oxygen-induced depression of surfactant activity.
Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:472481 |
Date | January 1976 |
Creators | Shields, Thomas Gillies |
Publisher | University of Glasgow |
Source Sets | Ethos UK |
Detected Language | English |
Type | Electronic Thesis or Dissertation |
Source | http://theses.gla.ac.uk/1048/ |
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