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A method to isolate the CTD of RNA Polymerase II for proteomics analysis

Indiana University-Purdue University Indianapolis (IUPUI) / In an effort to advance the methodology in analyzing RNAPII protein-protein interaction network and to determine the role of the CTD in controlling RNAPII transcription, we devised a method to specifically isolate the CTD-associated and CTD-less RNAPII to identify the proteins that interact with both the CTD and the globular core of RNAPII using novel purification scheme coupled to quantitative proteomics.

Identiferoai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/6179
Date12 1900
CreatorsAlakhras, Nada S.
ContributorsMosley, Amber L., Goebl, Mark G., Hurley, Thomas D., 1961-
Source SetsIndiana University-Purdue University Indianapolis
Languageen_US
Detected LanguageEnglish
TypeThesis

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